Disease
information
Diseases preventable by traditional vaccines
Polio
Polio is a viral infection that can result in permanent paralysis.
More than half of all cases are in children under age three but anyone
can be affected. Poliovirus is spread by person-to-person contact, and
contact with infected faeces or with secretions from the nose or mouth.
The virus establishes itself in the intestines, from where it can enter
the blood and invade the nervous system. In severe cases, the brainstem
can be infected, leading to respiratory failure and death. As the virus
multiplies it destroys nerve cells that activate muscles, particularly
in the legs, so that these muscles no longer function.
There is no cure for polio and immunization is the only effective way
to prevent the disease.
Since 1955, when the first effective polio vaccines were introduced,
the disease has been practically eliminated as a public health problem
in the industrialized countries. In 1988 the World Health Assembly
resolved to eradicate polio globally by the end of the year 2000.
In 12 years, thanks to the efforts of national governments working with
WHO, Rotary International, UNICEF and other partners, the number of
reported cases fell markedly from an estimated 350,000 to approximately
3,500 in 2000, according to WHO.
Today, polio is within sight of eradication worldwide. Large parts of
the world are polio-free, including the WHO Regions of the Americas,
Western Pacific, and Europe. However, the fragility of the progress is
reflected by recent outbreaks that have occurred where immunization
programmes have broken down because of war or other disruption. During
2000, reservoirs of poliovirus infection in South Asia and West/Central
Africa are targeted for accelerated eradication activities.
For more information see:
http://www.who.int/vaccines-polio
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Diphtheria
Diphtheria is a bacterial infection caused by the organism
Corynebacterium diphtheriae. The spread of infection requires close
contact between people.
When an infected person coughs or sneezes, droplets containing the
bacteria may enter the nose or throat of another person. While some
people experience few or no symptoms, others develop infection in the
throat and respiratory tract which can result in obstructed breathing
and death. Even with treatment, one in ten affected persons dies of the
disease. The infection can also cause damage to the heart and nervous
system. In tropical environments, the skin can be affected.
A safe and effective vaccine has long been available for diphtheria; it
is usually given together with vaccines against
tetanus and pertussis in the triple
vaccine known as DTP.
Today about 3000 people, mostly children, die of diphtheria each year.
There have been recent epidemics of the disease in Russia and other
Eastern European countries, and some of those affected have been adults.
For more information see:
http://www.who.org/vaccines-diseases/diseases/diphtheria_dis.htm
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Pertussis (whooping cough)
Pertussis is caused by infection with the bacterium Bordetella
pertussis. It is spread by droplets and direct contact and is highly
contagious.
Each year, about 296 000 people, mostly young infants, are killed by
the disease worldwide, and at least 45 million suffer from the illness
with prolonged and exhausting bouts of coughing that may continue for up
to 3 months. Some children also suffer seizures and neurological damage.
In recent years there have been reported increases in the incidence of
pertussis, including in several industrialized countries. Immunity to
infection is not permanent, even after infection with B. pertussis. This
partly explains the number of cases observed in adolescents and adults
in some countries.
Vaccines based on whole killed B. pertussis bacteria (known as
"whole-cell vaccines") have been used effectively and safely for several
decades to prevent infection.
Frequent, but usually mild, adverse reactions associated with these
vaccines, such as fever and localized side effects (redness, swelling
and pain at the site of injection) and a fear of extremely rare but
serious neurological events, reduced public acceptance of these vaccines
in the 1970s in some countries, and led to the development of a new
generation of vaccines that contain components of the bacterium instead
of all of it. These products, known as "acellular" vaccines, provoke
fewer of the frequent mild-to-moderate reactions seen with the
whole-cell vaccines, while severe adverse effects are equally rare in
both types of vaccine. The best acellular vaccines are as effective as
the best whole-cell vaccines. Acellular vaccines are considerably more
costly, however, and therefore whole-cell vaccines continue to be the
most widely used. Both whole-cell and acellular vaccines can be given in
combination with tetanus and diphtheria vaccines.
For more information see:
http://www.who.org/vaccines-diseases/diseases/pertussisvaccine.htm
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Tetanus
Tetanus is caused by infection with a bacterium, Clostridium tetani,
which is present in the soil, in animal dung and in faeces and enters
the body through wounds.
The bacterium produces a toxin which can make skeletal muscles
unusually rigid, and may result in spasms. Because these spasms may
affect the facial muscles, tetanus is sometimes known as lockjaw.
Ultimately, breathing may become difficult or impossible, resulting in
death. Neonatal tetanus, which affects newborn babies, usually results
from unsafe delivery in unhygienic conditions or without skilled birth
attendants. Unsterile cutting and care of the umbilical cord is a
frequent source of infection. As with many other infectious diseases,
poverty greatly increases families vulnerability.
There are an estimated 200 000 deaths from neonatal tetanus each year.
However the total number of tetanus deaths is much greater because
mothers, older children and others can also be affected. WHO estimates
that there are some 509 000 deaths altogether each year. Safe and
effective vaccines against tetanus has been available for decades and
are usually given with those for diphtheria
and pertussis.
Since the World Summit for Children in 1993 the WHO has been working to
eliminate neonatal tetanus as a public health problem. Strategies that
governments can employ to achieve this goal include:
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Ensuring that all pregnant women receive at least two doses of
tetanus vaccine
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Ensuring safe clean delivery for all women.
For more information see:
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Measles
Measles is a serious illness caused by a virus of the paramyxovirus
family. It is a highly contagious infection, spread by droplets, with an
incubation period of between 7 and 18 days.
Infected individuals may suffer fever, cough, rash, conjunctivitis,
diarrhoea, ear infections and pneumonia. A less frequent but serious
consequence of infection is encephalitis, or inflammation of the brain.
Measles kills an estimated 777,000 people, most of whom are children,
worldwide each year and also causes permanent disabilities for some of
its survivors, including blindness, deafness and brain damage.
Complications of the disease are much more common in low-income
countries, and in malnourished children, than in industrialized
countries.
Although there is no specific treatment for measles, the number of
cases of illness that prove fatal (between 3 per cent and 5 per cent in
developing countries, and up to 30 per cent in some situations) can be
reduced by effective case management, including oral rehydration therapy
and the use of vitamin A supplements.
For further information see:
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http://www.who.int/infectious-disease-report/pages/graph14.html
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http://www.who.org/vaccines-diseases/research/virus1.htm
More vaccines that are available now
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